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"Collagenase SANTYL Ointment 250g/unit"

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Recent studies have revealed the unique ability of clostridial collagenase and its degradative by-products to modulate cellular response and clinical outcomes. In this webinar, we will review: the unique mechanisms of action for Clostridium collagenase and new learnings. Clinical evidence for clostridium collagenase for management of pressure ulcers, diabetic and venous ulcers and burns. New Real-world evidence analysis from registry review for patients treated with Santyl. Evidence of economic benefits for including Santyl in the wound management algorithm.

Important Safety Information Indications: Collagenase SANTYL Ointment (“SANTYL”) is a prescription-only medication indicated for debriding chronic dermal ulcers and severely burned areas. Contraindications: SANTYL is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. Warning and Precautions: The optimal pH range of collagenase is 6 to 8. Higher or lower pH conditions will decrease the enzyme’s activity and appropriate precautions should be taken. The enzymatic activity is also adversely affected by certain detergents, and heavy metal ions such as mercury and silver which are used in some antiseptics. As such, the wound should be properly cleansed prior to application of SANTYL. Debilitated patients should be closely monitored for systemic bacterial infections because of the theoretical possibility that debriding enzymes may increase the risk of bacteremia. A slight transient erythema has been noted occasionally in the surrounding tissue, particularly when SANTYL was not confined to the wound. SANTYL is not indicated for wound closure. Discontinue use of SANTYL after granulation tissue is well-established. Adverse Reactions: No allergic sensitivity or toxic reactions have been noted in clinical use when used as directed. The risk information provided herein is not comprehensive. For complete prescribing information, please refer to the accompanying PI or visit: https://santyl.com/sites/default/files/2019-12/ SANTYL-PI.pdf. You are encouraged to report negative side effects of prescription drugs to FDA. Visit MedWatch or call 1-800-FDA-1088.

Reference: "Clinical Outcomes of SANTYL Treatment on Wound Care: Analysis of data from a large registry database"  Boxuan Li, Leo Nherera, Jaideep Banerjee.  Smith & Nephew Data on file

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